T Follicular Helper Cells in Autoimmune Disorders
نویسندگان
چکیده
منابع مشابه
Follicular helper T cells in autoimmune diseases.
Complete List of Authors: Papp, Gábor; University of Debrecen Medical Center, Institute of Medicine, Department of Clinical Immunology Szabó, Krisztina; University of Debrecen Medical Center, Institute of Medicine, Department of Clinical Immunology Szekanecz, Zoltán; University of Debrecen Medical Center, Institute of Medicine, Department of Rheumatology Zeher, Margit; University of Debrecen Me...
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CD4(+)T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity. Tfh cell differentiation depends on various factors including cell-surface molecule interactions, extracellular cytokines and multip...
متن کاملMemory T Follicular Helper CD4 T Cells
T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity. This specialized T helper subset provides help to cognate B cells via their expression of CD40 ligand, IL-21, IL-4, and other molecules. Tfh cells are characterized by their expression of the chemoki...
متن کاملSignaling pathways in T follicular helper cells.
Th cell functional subsets have unique transcriptional programs that form the molecular basis for T cell differentiation and functions. T follicular helper (TFH) cells have emerged as the main providers of T cell help to B cells during the germinal center (GC) reaction, where B cells undergo selection events through competition for Ag and for access to GC T cell-mediated prosurvival and differe...
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Background: The significance of cTfh cells and their subsets in atherosclerosis is not well understood. We measured the frequency of cTfh subsets in patients with different degrees of stenosis using flow-cytometry. Methods: Participants included high (≥50%; n = 12) and low (<50%; n = 12) stenosis groups, as well as healthy controls (n = 6). Results: The frequency of CCR7loPD-1hiefficient-cTfh w...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2018
ISSN: 1664-3224
DOI: 10.3389/fimmu.2018.01637